Lights out: deactivation of the phototransduction cascade.

Comparative Study of Two Various Percent of CO Injection Effect to Cascade Methanol Synthesis Reactor in the Presence of Long-term Catalyst Deactivation

GRK1-dependent phosphorylation of S and M opsins and their binding to cone arrestin during cone phototransduction in the mouse retina.

The shutoff mechanisms of the rod visual transduction cascade involve G-protein-coupled receptor (GPCR) kinase 1 (GRK1) phosphorylation of light-activated rhodopsin (R*) followed by rod arrestin binding. Deactivation of the cone phototransduction cascade in the mammalian retina is delineated poorly. In this study we sought to explore the potential mechanisms underlying the quenching of the phot...

Visual transduction in Drosophila.

The Drosophila phototransduction cascade has emerged as an attractive paradigm for understanding the molecular mechanisms underlying visual transduction, as well as other G protein-coupled signaling cascades that are activated and terminated with great rapidity. A large collection of mutants affecting the fly visual cascade have been isolated, and the nature and function of many of the affected...

Signal Amplification: Let's Turn Down The Lights

G protein activation by membrane-bound receptors initiates a chain reaction that amplifies cellular responses to external signals. In retinal photoreceptors, amplification by the phototransduction cascade is regulated by quickly switching off the visual pigment that acts as the receptor for light.

Speeding rod recovery improves temporal resolution in the retina

The temporal resolution of the visual system progressively increases with light intensity. Under scotopic conditions, temporal resolution is relatively poor, and may be limited by both retinal and cortical processes. Rod photoresponses themselves are quite slow because of the slowly deactivating biochemical cascade needed for light transduction. Here, we have used a transgenic mouse line with f...